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Bactrim dose based on trimethoprim -sulfamethoxazole (TMP-SMX), and the drug should be dispensed in the ratio appropriate for a 1:24 dose. [See Dosage and Administration (2.6), Specific Drug Dosage and Administration (2.4), Special Warning (3.9)]. Tetracycline-Specific Pregnancy Categories C and D Pregnant women receiving tetracycline must be informed of the high risk congenital infection in pregnancy and must not take the drug while pregnant unless advised to do so by a health care provider. Tetracycline-specific pregnancy categories C and D have been assigned to patients whose pregnancy was adjudicated to be at high risk of serious complications from tetracycline exposure, including placental abruption, intrauterine fetal growth restriction, preeclampsia, and preterm delivery. These canada drug rehab cost pregnancy categories apply to an estimated 10 20 percent of infants born to women using tetracycline. Tetracycline can pass into breast milk. This drug is generally excreted by a woman in 1 to 2 days and is eliminated from the body with minimal exposure to the fetus.(A) For infants born prematurely due to tetracycline exposure, the recommended age for initiation of the use tetracycline is 4 weeks, and infants are administered tetracycline at the dose recommended in adults during the first 2 weeks after birth. For infants born too early to receive the recommended dose of tetracycline, is increased every 3 to 4 weeks until the infant is old enough to receive the recommended dose of tetracycline. When the tetracycline-containing product is being used as a single agent, the dose may be increased to as high 30 mg per day of IV daily dose. The dose should not be administered more frequently or for a longer length of time than recommended for adults this indication due to possible renal insufficiency associated with this drug. In infants older than 6 months, the dose may be administered for as long 9 months. Special Considerations During Pregnancy and Lactation Pregnant women are at higher risk of tetracycline-related birth defects. The Centers for Disease Control and Prevention (CDC) recommends that women who are pregnant receive tetracycline while or should wait until they have completed their next menstrual period until taking this drug is considered appropriate.(See Concomitant Therapy in Boxed Warning) Other Considerations The possibility of maternal-fetal infection increases with concurrent use of antibiotics such as tetracycline and cephalosporins (particularly sulfamethoxazole). Therefore, when taking cefepime to lower the risk of a possible uterine infection, use at least 5 days before administration of tetracycline, and use tetracycline at the dose recommended in Adults (See Special Considerations). The effectiveness of maternal tetracycline use in reducing the risk of infection with other cephalosporins when taken cefepime given as a single dose is unknown at this time.(See Special Considerations in Boxed Warning) Use as Adjunctive Therapy for Osteoporosis in Patients with Dental Caries The effect of tetracycline on response to the treatment of osteoporosis has not been demonstrated in controlled clinical studies. Patients with osteoporosis should not be treated with oral antibiotics except in the event of severe infection or if clinically judged to be in septic shock where the benefits of concurrent tetracycline treatment outweigh the potential adverse effects. Tetracycline is contraindicated in infants under age 14 months whose mothers are taking antibiotics (see Drugs Flagyl generic price to Treat Infections, Inadvisable Use). Tetracycline should be discontinued in patients taking antibiotics for osteoporosis in patients with a clinically significant increase in bone density (GFR>25 mL/min) at or after a change from oral antibiotics when the change can be accomplished without the need for a change in tetracycline or any other antibiotic regimen. Dosage Forms and Strengths The following dosage forms and strengths are available: TMP-SMX: Oral tablet, USP. Oral tablet, USP. Trimethoprim-sulfamethoxazole (TMP-SMX): USP 0.8 mg/10 mg/15 mg; oral tablet, with 5% (w/v) tetracycline, USP 0.03 mg/0.1 mg/0.05 mg; oral tablet, with 10% (w/v) diclofenac or ibuprofen both, USP 0.

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